JCI NRF2 promotes neuronal survival in neurodegeneration
· We tested the effectiveness of this approach in 3 models of photoreceptor degeneration and in a nerve crush model AAV mediated delivery of NRF2 was more effective than SOD2 and catalase while expression of PGC1a accelerated photoreceptor death Since the NRF2 mediated neuroprotective effects extended to photoreceptors and retinal ganglion cells which are 2 very different types of